Ice
Cabin fever sets in next for Scully and Mulder, when they take their first honey moon to the Arctic in what looks like the first appearance of the black oil virus, which gets transmitted by little worms. Or it could just be some crazy primate that has been living in the ice all these years. Mulder gets accused of being infected and violent, Scully tackles a pilot and a scientist, and we see Scully and Mulder turn a gun on each other for the first time.
Truly a defining moment in their relationship.